C-Peptide Index may Predict endogenous insulin secretory capacity under non-fasting conditions: Study

The key findings of the study were:

• The CPI at 2 hours post-meal was significantly higher in the withdrawal group (2.97 ± 2.07) compared to the non-withdrawal group (1.93 ± 1.28) with a p-value of <0.001.

• This suggests that a higher post-meal CPI is associated with a greater likelihood of withdrawing from insulin therapy.

• CPI at 2 hours post-meal was an independent predictor of withdrawal from insulin therapy.

• It was also found to be a better predictor than fasting CPI.

• Six factors associated with insulin therapy withdrawal (age, duration of diabetes, creatinine, alanine aminotransferase, insulin therapy until hospitalization, and CPI at 2 hours post-meal) were used to create two clinical models using machine learning.

• The accuracy of the generated clinical models ranged from 78.3% to 82.6%.

The study concludes that the CPI at 2 hours post-meal is a clinically useful measure of endogenous insulin secretory capacity under non-fasting conditions. This measure can serve as a valuable tool for predicting the possibility of withdrawal from insulin therapy in patients with type 2 diabetes. This finding can help tailor treatment plans to individual patients' needs, potentially improving their overall quality of life.

Reference:

Iwamoto, Y., Kimura, T., Shimoda, M., Morimoto, Y., Watanabe, Y., Itoh, T., Sasaki, T., Mori, S., Kubo, M., Takenouchi, H., Dan, K., Iwamoto, H., Sanada, J., Fushimi, Y., Katakura, Y., Nakanishi, S., Mune, T., Kaku, K., & Kaneto, H. (2024). C‐peptide index at 2 h post‐meal is a useful predictor of endogenous insulin secretory capacity and withdrawal from insulin therapy in subjects with type 2 diabetes. Diabetes, Obesity & Metabolism. https://doi.org/10.1111/dom.15595