Elevated Hba1C During First Trimester Linked With Adverse Pregnancy Outcome
Gestational diabetes (GDM) is a common pregnancy complication associated with adverse maternal and fetal outcomes including an increased risk for type 2 diabetes and cardiovascular disease later in life in mothers and an increased risk for macrosomia and obesity in offspring. However, a recent study suggests that elevated glycated haemoglobin (HbA1c) in the first trimester (HbA1c-FT) is linked with adverse pregnancy events in non-GDM Asian Indians. The updated study findings were published in the Journal of Diabetes and its Complications on April 13, 2022.
HbA1c analysis was endorsed as a screening test for unrecognised diabetes in both the general population and in early pregnancy. A few prior studies have examined if HbA1c measured in the first trimester is useful for the early prediction of GDM. However, its significance in non-GDM individuals is understudied. Therefore, Dr John Punnose and his team conducted a study to determine the association of HbA1c-FT with adverse events among pregnant Asian Indian women without GDM.
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