Elevated TyG Index tied to Diabetic Retinopathy Risk especially in Poor Glycemic Control: Study
Researchers have found in a new study that elevated triglyceride-glucose (TyG) index, a marker of insulin resistance, was strongly related to diabetic retinopathy (DR) risk in type 2 diabetes mellitus (T2DM) patients. A recent study was conducted by Xiaohua Wan and fellow researchers published in the journal Diabetes, Metabolic Syndrome and Obesity. The findings indicated that a high TyG index and risk of DR were highest among patients with poor glycemic control (HbA1c > 9%), emphasizing the need to use the TyG index as a risk stratification tool in the management of T2DM.
Diabetic retinopathy is a microvascular DM complication and an important cause of acquired blindness among the working-aged population. Insulin resistance (IR) or diminished cellular sensitivity to insulin is the core mechanism for developing T2DM and vascular complications associated with it. Glycated hemoglobin A1c (HbA1c) is universally accepted as a reliable marker for the assessment of long-term glycemic control, and has been invariably proven to be related to the development of both microvascular and macrovascular complications of DM
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