Estimated glucose disposal rate may predict Renal Decline in T2DM Patients

• Researchers enrolled 956 T2DM patients.
• These patients had baseline eGFR of ≥60 mL/min/1.73m2 and a 5-year follow-up.
• Rapid eGFR decline, eGFR <60 mL/min/1.73m2, and composite renal endpoint consisting of 50% eGFR decline, doubling of serum creatinine, or end-stage renal disease were the primary outcomes measured.
• eGFR decline was experienced by 23.95% of patients.
• 21.97% had eGFR <60 mL/min/1.73m2.
• There were 12.13% of patients with the composite renal endpoint.
• eGDR presented a relationship with follow-up eGFR and a per cent change in eGFR.
• eGDR <6.34 mg/kg/min was an independent risk factor for rapid eGFR decline, eGFR<60 mL/min/1.73m2or the composite renal endpoint.
• Compared with eGDR of 5.65∼6.91 mg/kg/min, eGDR levels >8.33 mg/kg/min decreased the risk of rapid eGFR decline by 75%, eGFR<60 mL/min/1.73m2 by 60%, and the composite renal endpoint by 61%.
• eGDR was associated with primary outcomes as shown in Subgroup analysis performed by sex, age, and diabetes duration

They said, “Lower eGDR is a predictive factor for renal deterioration in T2DM patients.”

Further reading:

https://academic.oup.com/jes/advance-article/doi/10.1210/jendso/bvad069/7188163