Fasting blood sugar and BMI during childhood predictors of Diabetes: Study

On analysis the following key facts emerged.

• The sample included 6,738 participants. Of these, 436 (6.5%) reported onset of T2DM between ages 20 and 59 (mean 40.8) years, and 86% of them reported use of a confirmed antidiabetic medication.
• BMI and glucose (age and sex standardized) were associated with incident T2DM after adjustment for cohort, country, sex, race, age, and calendar year of measurement.
• Increasing levels of childhood BMI and blood sugar were related to an incrementally increased risk of T2DM beginning at age 30 years, beginning at cut points <95 percentile for BMI and <100 mg/dL for glucose.
• Insulin was positively associated with adult T2DM after adjustment for BMI and glucose and added to T2DM discrimination.

"Childhood BMI and glucose, individually and in combination, are predictors of adult T2DM risk at levels currently considered to be mostly within the normal range. Insulin has the potential to be an additional predictor, and its clinical utility could be improved by developing a more standardized approach to the measurement in the future. The provisionally suggested cut points, which are lower than currently defined as abnormal, suggest revisiting the criteria of childhood BMI and glucose as predictors of adult T2DM risk" concluded the team.Primary source: Diabetes Care

For full article click on link: Hu, T., Jacobs, D. R., Sinaiko, A. R., Bazzano, L. A., Burns, T. L., Daniels, S. R., Steinberger, J. (2020). Childhood BMI and Fasting Glucose and Insulin Predict Adult Type 2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium. Diabetes Care, dc200822.