Good CV health critical for prevention of type 2 diabetes regardless of genetics: Study
Netherlands: Results from a recent study have underlined the importance of favorable cardiovascular health (CVH) for the prevention of type 2 diabetes in middle-aged people regardless of their genetic susceptibility. The study appears in the European Journal of Preventive Cardiology.
Type 2 diabetes (T2D) Mellitus is a common chronic condition characterized by impaired glucose and insulin metabolism. About 463 million are said to be affected by T2D which is expected to increase to 700 million by 2045. Multilevel intervention measures are warranted to improve T2D prevention as its pathogenesis is driven by varied genetic and non-genetic factors.
Cardiovascular health (CVH) was introduced by the American Heart Association (AHA) in 2010 as part of the AHA impact goals for promoting CVH and reducing deaths from cardiovascular disease (CVD). CVH includes seven health factors and health behaviors associated with CVD and aging. It is not known if the impact of CVH on lifetime risk of incident T2D is affected by genetic predisposition.
To fill this knowledge gap, Fariba Ahmadizar, Erasmus University Medical Center, Rotterdam, the Netherlands, and colleagues aimed to evaluate the lifetime risk for incident T2D across different CVH categories by using data from the large prospective population-based Rotterdam Study (RS). Further, they investigated the role of T2D genetic variants on the lifetime risk of incident T2D across different CVH.
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