Gout and CKD Synergy Sharply Elevates Cardiovascular Risks and Mortality in Diabetes Patients: Study Reveals
South Korea: A recent study published in Diabetes, Obesity and Metabolism has revealed the detrimental interplay between gout and chronic kidney disease (CKD) in individuals with type 2 diabetes, significantly elevating the risks of myocardial infarction (MI), stroke, and mortality. While gout alone did not increase these risks substantially, its coexistence with CKD was markedly amplified.
"Compared to individuals without gout or CKD, those with both conditions exhibited a 71% higher risk of MI, a 46% greater risk of stroke, and a 78% increased risk of death," the researchers reported.
Nan Hee Kim, Korea University Ansan Hospital, Ansan, Republic of Korea, and colleagues aimed to investigate the influence of gout on cardiovascular disease and mortality risks in patients with type 2 diabetes and assess the role of chronic kidney disease as a potential modifier of this relationship.
For this purpose, the researchers utilized the Korean National Health Insurance Service database to analyze data from 757,378 individuals with type 2 diabetes. Participants were categorized into four groups: CKD−Gout−, CKD−Gout+, CKD+Gout−, and CKD+Gout+. To evaluate the risks of myocardial infarction, ischemic stroke, and mortality, Cox proportional hazard models were employed, adjusting for cardiometabolic factors to ensure robust findings.
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