High Baseline Serum Uric Acid Linked to Increased Cardiovascular and Renal Risks in Type 2 Diabetes: Study
Brazil: A recent study conducted as part of the Rio de Janeiro Type 2 Diabetes Cohort has emphasized the significant role that baseline serum uric acid (sUA) levels and their subsequent changes play in predicting key health outcomes in individuals with type 2 diabetes (T2D).
The prospective cohort study, published in the Journal of Diabetes and its Complications, found that elevated baseline sUA levels were associated with a higher risk of cardiovascular events, renal complications, and peripheral neuropathy in patients with type 2 diabetes.
"Baseline sUA levels were linked to major adverse cardiovascular events (HR: 2.4), renal failure, and microalbuminuria, with women showing a stronger cardiovascular risk association (HR: 2.6) compared to men (HR: 1.2). Additionally, changes in sUA levels were specifically connected to an increased risk of renal failure (HR: 2.4)," the researchers reported.
Serum uric acid, a substance typically associated with gout and kidney disease, has been emerging as an important biomarker for complications in diabetes. Claudia R.L. Cardoso, Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine; Universidade Federal do Rio de Janeiro, Brazil, and colleagues aimed to examine the relationships between baseline and changes in serum uric acid (sUA) levels and the risks of cardiovascular and microvascular outcomes, as well as mortality, in a type 2 diabetes cohort.
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