High-sensitivity CRP and monocyte to HDL ratio associated with Increased Type 2 Diabetes Risk: BMC study

A recent study published in the Journal of Translational Medicine explored the intricate relationship between monocytic inflammation, C-reactive protein (CRP) and the onset of type 2 diabetes (T2D). The investigation looked into the association between systemic inflammation that assessed by joint cumulative high-sensitivity C-reactive protein (CumCRP), monocyte to high-density lipoprotein ratio (CumMHR)and the incidence of T2D within the general population.

Over 40,000 nondiabetic individuals participated in this prospective real-life cohort study, with biennial follow-ups that spanned from 2010/2011 to December 31, 2020. Through rigorous multivariable Cox regression analyses, the team evaluated adjusted hazard ratios (aHRs) of incident diabetes.

The findings revealed that over a median follow-up of nearly eight years, 4848 cases of T2D emerged. CumMHR and CumCRP was found to be significant predictors of T2D, both independently and in conjunction. The elevated CumMHR levels were found to increase the risk of developing diabetes across all CumCRP strata by indicating a relationship between these markers. The observation that individuals with concurrent elevations in CumMHR and CumCRP underwent the highest risk of T2D by emphasizing the importance of considering multiple markers in assessing diabetes risk was striking.