High-sensitivity CRP and monocyte to HDL ratio associated with Increased Type 2 Diabetes Risk: BMC study

A recent study published in the Journal of Translational Medicine explored the intricate relationship between monocytic inflammation, C-reactive protein (CRP) and the onset of type 2 diabetes (T2D). The investigation looked into the association between systemic inflammation that assessed by joint cumulative high-sensitivity C-reactive protein (CumCRP), monocyte to high-density lipoprotein ratio (CumMHR)and the incidence of T2D within the general population.

Over 40,000 nondiabetic individuals participated in this prospective real-life cohort study, with biennial follow-ups that spanned from 2010/2011 to December 31, 2020. Through rigorous multivariable Cox regression analyses, the team evaluated adjusted hazard ratios (aHRs) of incident diabetes.

The findings revealed that over a median follow-up of nearly eight years, 4848 cases of T2D emerged. CumMHR and CumCRP was found to be significant predictors of T2D, both independently and in conjunction. The elevated CumMHR levels were found to increase the risk of developing diabetes across all CumCRP strata by indicating a relationship between these markers. The observation that individuals with concurrent elevations in CumMHR and CumCRP underwent the highest risk of T2D by emphasizing the importance of considering multiple markers in assessing diabetes risk was striking.

This study highlighted the influence of demographic and clinical factors such as age, sex, hypertension, dyslipidemia and prediabetes status on the observed risk. This precise understanding underlines the complexity of T2D development and the need for personalized risk assessment strategies. The addition of CumMHR and CumCRP to established risk factors significantly enhanced risk prediction and reclassification of diabetes by improvements in C-statistics and net reclassification improvement.

Reference:

Wu, D., Chen, G., Lan, Y., Chen, S., Ding, X., Wei, C., Balmer, L., Wang, W., Wu, S., & Xu, W. (2024). Measurement of cumulative high-sensitivity C-reactive protein and monocyte to high-density lipoprotein ratio in the risk prediction of type 2 diabetes: a prospective cohort study. In Journal of Translational Medicine (Vol. 22, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12967-024-04895-4