Higher TyG index tied to risk of elevated BP in healthy people

The study demonstrated the following findings:

· The mean systolic/diastolic BP and HTN prevalence increased with the TyG index.

· The continuous TyG index had a strong dose-response relationship with an increased risk of elevated BP, pre-HTN, and HTN.

· The highest TyG index quartile was significantly associated with higher odds of having high BP (odds ratio [OR], 1.52), pre-HTN (OR, 2.22), and HTN (OR, 4.24) compared with the lowest TyG index quartile.

The findings from the population-based cross-sectional study showed that the TyG index is positively related to BP elevation. The significant associations between the TyG index and BP were maintained even after the adjustments for conventional risk factors. The researchers noted that the study participants were healthy people without any history of cardiovascular disease, hypertension, or renal failure or not taking anti-diabetic or antihyperlipidemic medications.

"These results indicate that the TyG index is independently associated with blood pressure and may help identify and follow individuals at hypertension risk," the researchers wrote in their conclusion. "There is a need for further studies to longitudinally investigate the cause-effect relationship between the TyG index and BP."

Reference:

Lee, DH., Park, J.E., Kim, S.Y. et al. Association between the triglyceride-glucose (TyG) index and increased blood pressure in normotensive subjects: a population-based study. Diabetol Metab Syndr 14, 161 (2022). https://doi.org/10.1186/s13098-022-00927-5