hsCRP useful biomarker for early diagnosis of prediabetes: Study

The study enrolled a total of 200 participants, including 100 cases and 100 controls who were age- and gender-matched. Enrollment was done according to the World Health Organisation criteria for pre-diabetes. All the cases and controls underwent a detailed history, physical examination, anthropometric measurements, and biochemical analysis. The biochemical analysis included blood glucose levels, lipid profile, and hsCRP.

The authors found that the mean hsCRP in pre-diabetics 2.17 ± 0.72 mg/L was significantly higher than controls (0.66 ± 0.22 mg/L). High sensitivity CRP was significantly and positively correlated to age, body mass index (BMI), total cholesterol, low-density lipoprotein, cholesterol, and waist-hip ratio.

The researchers concluded, "Raised level of hsCRP was associated with pre-diabetes and also correlated with age, higher BMI, higher cholesterol, higher low-density lipoprotein, and higher waist-hip ratio."

Reference:

 Ghule A, Kamble T K, Talwar D, et al. (October 28, 2021) Association of Serum High Sensitivity C-Reactive Protein With Pre-diabetes in Rural Population: A Two-Year Cross-Sectional Study. Cureus 13(10): e19088. doi:10.7759/cureus.19088