Hypothyroid patients with elevated inflammatory marker levels at elevated risk for MASLD: Study
A new study published in the journal of Nature Scientific Reports showed that the patients with hypothyroidism have increased risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD) when compared to those without hypothyroidism.
Lipid buildup in liver cells is a hallmark of non-alcoholic fatty liver disease (NAFLD). From basic hepatic steatosis to non-alcoholic steatohepatitis (NASH), which can lead to advanced fibrosis, cirrhosis, and eventually chronic liver failure, NAFLD includes a wide range of liver pathologies.
The term metabolic dysfunction-associated fatty liver disease (MASLD) has taken the role of NAFLD in recent years. The association between hypothyroidism and MASLD has been the subject of a significant number of observational research. However, the results are still unclear, with inconsistent findings from different investigations.
Thus, a sizable population cohort from the UK Biobank was used in the current study to methodically investigate the relationship between hypothyroidism and MASLD. To investigate the underlying possible processes and offer fresh population-based evidence for the influence of hypothyroidism on the risk of MASLD, further stratified, mediation, and nonlinear analyses were conducted.
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