Impaired Fasting Glucose and Sulfonylureas Raise Heart Risk in Inflammatory Arthritis, reveals study
Researchers have discovered in a new study that impaired fasting glucose (IFG) and sulfonylurea use are independently linked with an enhanced risk of major cardiovascular events (MACE) in inflammatory arthritis (IA) patients, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA). The findings of the study underscore vigilance in screening fasting glucose level and adjusting choices of anti-diabetic therapy for patients with IA, as such patients already possess heightened cardiovascular risk. The study was conducted by Huan Meng and fellow researchers published in BMC Diabetology & Metabolic Syndrome.
This was a retrospective, population-based cohort study that made use of data available from The Hospital Authority Data Collaboration Lab in Hong Kong. Patients with IA were enrolled between January 2006 and December 2015, and follow-up data were available up to December 2018. A total of 13,905 patients were included in the study, of whom 12,233 had RA and 1,672 had PsA. Time-dependent Cox proportional hazards regression models were used by researchers to examine the relationships between fasting glucose levels, use of anti-diabetic medications, and the risk of a first MACE in this population.
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