Increased fasting blood sugar variability risk factor for osteoporotic fractures

All participants were followed from the date of the third examination to the first occurrence of an endpoint event. 57295 included participants were divided into three groups according to the SD of FPG levels. For further analysis of the effects of different FPG-SD groups on osteoporotic fracture risk, a Cox proportional hazards model was performed.

The study led to the following findings:

• During a median follow-up time of 11.00 years, 772 new osteoporotic fracture cases were documented.
• When evaluating the FPG-SD level as a categorical variable, the HRs for osteoporotic fractures were 1.07 for T2 and 1.32 for T3 when compared with T1.
• Increased FPG variability was associated with a greater risk of osteoporotic fractures in people with diabetes than in those without diabetes (47% versus 32%).

"Our study provides the first report on the effect of FPG variability on the risk of osteoporotic fracture in the entire community population," the researchers wrote. "We found that increased FPG variability was an independent predictor of incident osteoporotic fracture, particularly in individuals older than 50 years old, diabetes patients, nonobese individuals, and individuals with positive FPG-SD variability."

Reference:

Liu, Ri, et al. "The Impact of Fasting Plasma Glucose Variability On Osteoporotic Fractures." Frontiers in Endocrinology, vol. 14, 2023, p. 1187682.