Insulin resistance linked with increased cardiovascular risk not kidney risk in diabetes patients: Study
A recent study published in the Journal of Diabetes Care investigated the association between insulin resistance, cardiorenal risk and the effectiveness of finerenone to the management of type 2 diabetes.
This FIDELITY study involved a total of 13,026 patients with type 2 diabetes and examined whether insulin resistance, measured by estimated glucose disposal rate (eGDR), influence the risk of cardiovascular and kidney complications. Furthermore, if the risk affected the effectiveness of finerenone when compared to a placebo was examined.
The results showed that patients with lower eGDR had a significantly higher incidence of cardiovascular events compared to those with higher eGDR, irrespective of treatment that indicates insulin resistance. The incidence rate of cardiovascular events per 100 patient-years for finerenone was 5.18 and for placebo was 6.34 in the lower eGDR group, versus 3.47 for finerenone and 3.76 for placebo in the higher eGDR group.
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