Later age of menopause tied to lower risk of type 2 diabetes: Study

Based on the study, the following findings were revealed:

• After full adjustment, women with a later age of menopause (>54 y) were more likely to have T2DM (odds ratio =1.401) than those in the reference group (4453 y).
• After multiple adjustments, each 1-year increase in the age at onset of menopause was associated with a 0.021 mmol/L increase in FPG, 0.048 mmol/L increase in2hPBG, and 1.540 decreases in HOMA-ß, but no changes in HOMA-IR.
• Later age of menopause was associated with overweight/general obesity (odds ratio = 1.416).
• BMI partially mediated the association between age at menopause and FPG and 2hPBG, and the proportion of the effect was 5.42% and 7.69%, respectively.
• BMI suppressed the association between age at menopause and HOMA-ß, and the proportion of the suppressing effect was 9.54%.

"The later age of menopause was positively related to T2DM," wrote the authors. "The association between age at menopause and glucose status was partially mediated by BMI which also suppressed the association between menopause and HOMA-ß. Prospective studies are warranted to confirm this association."

Reference:

Zhao, Yijing MS; Wang, Su MS; Yang, Yu PHD; Cao, Wen PHD; Chen, Kun PHD; Wang, Kun PHD Mediation effect of body mass index on the association between age at menopause and type 2 diabetes mellitus in postmenopausal Chinese women, Menopause: May 2022 - Volume 29 - Issue 5 - p 590-598 doi: 10.1097/GME.0000000000001946