Modest weight loss tied to significant improvement in NAFLD: claims study

Data analysis revealed the following facts.

• For every 1 kg of weight loss, there was a 0.83-unit reduction in alanine aminotransferase, a 0.56-unit reduction in aspartate transaminase, and a 0.77% drop in steatosis assessed by histology or radiology.
• A dose–response relationship was identified with regard to liver inflammation, ballooning, and resolution of NAFLD or nonalcoholic steatohepatitis; there was limited evidence of a dose–response relationship with NAFLD activity score or fibrosis.
• Forty-three studies (BWMPs: 26, pharmacotherapy: 9, surgery: 8) with 2809 participants were included. The median follow-up was 6 (interquartile range: 6) months.
• The direction of effect was generally consistent but the estimates imprecise. Every 1 kg of weight lost was associated with 0.83-unit (95% CI: 0.53 to 1.14, p < 0.0001, I2 = 92%, n = 18) reduction in alanine aminotransferase (U/L), 0.56-unit (95% CI: 0.32 to 0.79, p < 0.0001, I2 = 68%, n = 11) reduction in aspartate transaminase (U/L), and 0.77 percentage point (95% CI: 0.51 to 1.03, p < 0.0001, I2 = 72%, n = 11) reduction in steatosis assessed by radiology or histology.

For full article follow the link:The Effect of the Magnitude of Weight Loss on Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Metab. Clin. Exp. 2020 Nov 28;[EPub Ahead of Print], DA Koutoukidis, C Koshiaris, JA Henry, M Noreik, E Morris, I Manoharan, K Tudor, E Bodenham, A Dunnigan, SA Jebb, P Aveyard

Primary source: Metabolism - Clinical and Experimental