New onset diabetes may predict development of low-risk pancreatic mucinous cysts: Study
New onset diabetes may accurately estimate the development of low-risk mucinous cysts, suggests a study published in the Pancreatology Journal.
Pancreatic cancer is one of the most common cancer worldwide; also, it is associated with a high mortality rate. The five-year survival rate in all patients is just 5% and has not altered significantly over the past five decades. The relationship between diabetes mellitus and pancreatic cancer has been known for over 125 years, some studies have proved that the chances of patients with low-risk lesions developing pancreatic cancer are higher as compared to healthy individuals. Hence, it is essential for regular continued surveillance in patients with low-risk lesions.
A study was conducted by a group of researchers from Columbia University Irving Medical Center, NY, USA to investigate the association between new-onset diabetes and progression in patients with low-risk mucinous cysts.
The researchers assessed a prospectively maintained cohort of a total of 442 patients with a suspected mucinous cyst without worrisome features (WF) or high-risk stigmata (HRS).
Additionally, Multivariable Cox models were developed for development to worrisome features and high-risk stigmata, with diabetes status, formulated as both time independent and dependent covariates.
The adjusted cumulative risk of progression was calculated using the corrected group prognosis method.
The findings of the study are as follows:
Ø The 5-year total progression rates to worrisome features and high-risk stigmata were 12.8 and 3.6%, respectively.
Ø The new-onset diabetes was strongly linked with progression to high-risk stigmata (HR = 11.6; 95%CI, 3.5–57.7%).
Ø The new-onset diabetes was not linked with worrisome features.
Ø Among patients with cysts less than 10 mm at baseline, those who developed new onset diabetes had a 5-year adjusted total risk of progression to high-risk stigmata of 8.6% as compared to only 0.8% for patients without new-onset diabetes.
Ø Among patients with cysts between 20–29 mm, those who developed new-onset diabetes during surveillance had a 5-year adjusted cumulative risk of progression of 53.5% compared to only 7.5% for patients without new-onset diabetes.
The researchers concluded that new-onset diabetes may accurately estimate the development of low-risk mucinous cysts. Pending validation with large-scale studies, these findings bolster routine diabetes examination among patients screened for suspected Intraductal Papillary Mucinous Neoplasm or Mucinous Cystic Neoplasms
Reference
A study titled, "New onset diabetes predicts progression of low risk pancreatic mucinous cysts" by Schweber A published in the Pancreatology Journal.
https://doi.org/10.1016/j.pan.2020.09.015
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