New onset diabetes may predict development of low-risk pancreatic mucinous cysts: Study

Additionally, Multivariable Cox models were developed for development to worrisome features and high-risk stigmata, with diabetes status, formulated as both time independent and dependent covariates.

The adjusted cumulative risk of progression was calculated using the corrected group prognosis method.

The findings of the study are as follows:

Ø The 5-year total progression rates to worrisome features and high-risk stigmata were 12.8 and 3.6%, respectively.

Ø The new-onset diabetes was strongly linked with progression to high-risk stigmata (HR = 11.6; 95%CI, 3.5–57.7%).

Ø The new-onset diabetes was not linked with worrisome features.

Ø Among patients with cysts less than 10 mm at baseline, those who developed new onset diabetes had a 5-year adjusted total risk of progression to high-risk stigmata of 8.6% as compared to only 0.8% for patients without new-onset diabetes.

Ø Among patients with cysts between 20–29 mm, those who developed new-onset diabetes during surveillance had a 5-year adjusted cumulative risk of progression of 53.5% compared to only 7.5% for patients without new-onset diabetes.

The researchers concluded that new-onset diabetes may accurately estimate the development of low-risk mucinous cysts. Pending validation with large-scale studies, these findings bolster routine diabetes examination among patients screened for suspected Intraductal Papillary Mucinous Neoplasm or Mucinous Cystic Neoplasms

Reference

A study titled, "New onset diabetes predicts progression of low risk pancreatic mucinous cysts" by Schweber A published in the Pancreatology Journal.

https://doi.org/10.1016/j.pan.2020.09.015