Newly formulated herbal drug may lower blood sugar in early diabetes: Study

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2021-01-25 04:46 GMT | Update On 2021-01-25 07:26 GMT

Sri Lanka: A newly formulated herbal drug of C. grandis (500 mg per day) significantly improved blood sugar control in patients with newly diagnosed type 2 diabetes (T2D), according to a recent study in the journal Phytomedicine.

Several preclinical studies have shown the aqueous leaves extract of Coccinia grandis (Linn.) Voigt (Cucurbitaceae) to be promising for the in vivo and in vitro diabetes treatment. The present study by Keddagoda Gamage Piyumi Wasana, University of Ruhuna, Galle, Sri Lanka, and colleagues evaluated the efficacy and safety of a newly developed herbal formulation of C. grandis in newly diagnosed patients with type 2 diabetes mellitus.

For the purpose, the researchers conducted a three months long, randomized, double blind, placebo controlled clinical trial in patients with newly diagnosed T2D. The trial from the University Medical Clinic, Teaching Hospital, Karapitiya, Galle, Sri Lanka, recruited 158 newly diagnosed patients with T2DM based on fasting plasma glucose (FPG) concentration. They were randomly assigned to receive 500 mg of herbal drug (test group; n = 79) or placebo drug (placebo group; n = 79) once daily for three months.

Patients and investigators were blinded for the treatment. Percentage of glycated hemoglobin (HbA1C %), insulin and lipid profile parameters were estimated at the base line and at the end of the intervention. Serum concentration of fructosamine was assessed at every other visit of the trial.

The homeostatic model assessment for insulin resistance (HOMA-IR), atherogenic index (AI), cardio-protective index (CPI) and coronary risk index (CRI) were calculated. Fasting plasma glucose concentration, renal and liver toxicity parameters, hematological parameters, blood pressure (BP) were assessed throughout the study in two weekly intervals till the end of three months.

A total number of 145 patients completed the entire clinical trial period successfully.

Key findings of the study include:

Mean (SD) changes of variables from the baseline to the end of the intervention in test and placebo groups were 0.65 and 0.08 for HbA_1C %, 1.91 and -1.28 for insulin, 0.02 and -0.01 for frucosamine, 1.51 and 0.05 for FPG, 1.73 and -0.37 for HOMA-IR, 0.16 and -0.04 for TG, 0.07 and -0.02 for VLDL-C respectively.
The herbal drug of C. grandis was unable to change other outcome variables significantly when compared to the placebo.
All the renal, liver and toxicity parameters, hematological parameters and BP were within the normal physiological reference ranges at each visit.

"Our findings demonstrate that treatment with herbal drug of C. grandis (500 mg per day) for three months for patients with newly diagnosed T2DM significantly improved their glycemic and selected lipid profile parameters with well tolerated safety," concluded the authors.

"Efficacy and safety of a herbal drug of Coccinia grandis (Linn.) Voigt in patients with type 2 diabetes mellitus: A double blind randomized placebo controlled clinical trial," is published in the journal Phytomedicine.

DOI: https://www.sciencedirect.com/science/article/abs/pii/S0944711320302622

Article Source : journal Phytomedicine

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Medha Baranwal

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Newly formulated herbal drug may lower blood sugar in early diabetes: Study

Similar News

Semaglutide and Liraglutide linked to Elevated Risk of Optic Nerve Damage in Seniors With Type 2 Diabetes: JAMA

Study Links High Stress Hyperglycemia Ratio to Diabetic Retinopathy Progression and Post-Surgery Complications

Non-Invasive Saliva Test May Detect Early Signs of Diabetes and Obesity: Study Finds

Methylglyoxal Independently Contributes to Liver Fibrosis in Obesity: Study

Tirzepatide Matches dulaglutide in Heart Protection, Offers Added Benefits in SURPASS-CVOT trial

Sleep Problems Worsen Diabetes Distress in Type 2 Diabetes, finds study

Fatty Liver Index Predicts Hepatocellular Carcinoma Risk in T2DM Without Cirrhosis: Study

High Body Fat, Not BMI, Linked to Increased Risk of Death and Heart Disease: Study Finds