Prediabetes Linked to Higher Mortality in Younger Adults: JAMA
Researchers have found in a cohort study that prediabetes was significantly associated with increased mortality only among adults aged 20–54 years, possibly due to underlying metabolic or behavioral risk factors. Previous research on this link has shown conflicting results. The study was published in JAMA Network by Obinna E. and colleagues.
Prediabetes is generally accepted to be a risk factor for type 2 diabetes and is also associated with cardiovascular disease and increased risk of all-cause and cause-specific mortality. The contribution of demographic, lifestyle, and comorbidity factors in this relationship has not been well understood. This study demonstrates that controlling for these factors, the mortality risk remains significant only among young adults—laying emphasis on early intervention among young adults.
According to STROBE guidelines, this retrospective cohort study employed the data from NHANES linked to the National Death Index mortality records. The sample consisted of 38,093 adults aged 20 years and older who completed interviews and physical examinations between 2005 and 2018 and had valid mortality follow-up information.
Prediabetes was self-reported or defined as an HbA1c of 5.7% to 6.4%. Participants were sorted by demographics, lifestyle characteristics, and comorbidities. Race and ethnicity were reported by the participants and categorized as non-Hispanic Black, non-Hispanic White, or other.
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