Renal Dysfunction Raises Risk of Vertebral Fractures in T2DM Patients, reveals study
Researchers have demonstrated that renal impairment highly increases the risk of vertebral fracture among type 2 diabetes mellitus (T2DM) patients, according to data from a five-year longitudinal follow-up study. The research showed specific types of renal impairment such as low estimated glomerular filtration rate (eGFR) and proteinuria to be independently associated with a high fracture risk. These findings emphasize the need for closer follow-up and preventive measures for bone health in diabetic patients presenting with evidence of kidney disease. The study was published in Diabetes, Metabolic Syndrome and Obesity by Nandong Hu and colleagues.
T2DM is a proven risk factor for both chronic kidney disease and decreased bone mineral density. Vertebral fractures (VFs), typically silent but clinically significant, are more prevalent in this population. However, the direct longitudinal association between kidney impairment and vertebral fracture risk has rarely been explored. This study attempted to fill that gap by exploring the influence of different manifestations of renal dysfunction decrease in eGFR, proteinuria, or both on the risk of vertebral fractures in older persons with T2DM.
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