Saffron supplementation with aerobic exercise may lower blood sugar and inflammation in obese diabetics

Physical inactivity and sedentary behaviour are the major risk factors for type 2 diabetes. Thus, aerobic training, the most favoured training method in the world, could be a crucial strategy to counter T2DM. Aerobic training lowers the risk of many conditions, including T2DM, heart disease, obesity, metabolic syndrome, high blood pressure, stroke, and certain cancer types.

Another strategy to fight T2DM is supplementation. However, studies have shown that taking chemical supplements may lead to adverse side effects, which has shifted the attention towards the use of organic supplements with no or fewer side effects. Saffron is one of the most popular organic supplements with several medical applications.

Against the above background, Ali Rajabi, University of Mohaghegh Ardabili, Ardabil, Iran, and colleagues aimed to examine the effects of 8-week aerobic training and saffron supplementation on metabolism and inflammation in middle-aged obese women with T2DM.

The study included thirty-two obese women with type 2 diabetes mellitus. They were randomly categorized into four groups; each group comprised eight women:-- placebo + training (PT), saffron + training (ST), saffron supplementation (SS), and placebo (P). The PT and ST groups conducted eight weeks of aerobic training (three sessions per week at 60–75% HRmax). Saffron powder at a daily dose of 400 mg was given to the SS and ST groups for eight weeks. Blood samples were collected following 12 h of dating, 48 h before the first session of aerobic training, 48 h and two weeks after the last session of AT.

The study led to the following findings:

• Saffron supplementation, aerobic training and their combination affected homeostatic model assessment for insulin resistance (HOMA-IR), body mass index (BMI), and serum levels of insulin, interleukin-6 (IL-6), adiponectin, high-density lipoprotein cholesterol (HDL-C), cholesterol, and triglyceride (TG).
• Body weight, body fat percentage, serum glucose levels, resistin, tumour necrosis factor-alpha (TNF-α), low-density lipoprotein cholesterol (LDL-C), and irisin showed remarkable changes in the ST group only.
• The researchers observed a significant difference between all factors in post-training and follow-up in the ST group.

"Supplementation with saffron at a dose of 400 mg/day in combination with aerobic exercise improves metabolism, lipid profile, blood sugar status, and inflammation in patients with type 2 diabetes, and these changes are continual at up to 2 weeks of detraining," the researchers concluded.

Reference:

Rajabi A, Khajehlandi M, Siahkuhian M, Akbarnejad A, Khoramipour K, Suzuki K. Effect of 8 Weeks Aerobic Training and Saffron Supplementation on Inflammation and Metabolism in Middle-Aged Obese Women with Type 2 Diabetes Mellitus. Sports (Basel). 2022 Oct 30;10(11):167. DOI: 10.3390/sports10110167. PMID: 36355818