Sarcopenic obesity elevates risk of CKD among diabetes patients

"Accumulation of uremic toxins, chronic inflammation, insulin resistance, hormonal imbalance, malnutrition, vitamin D deficiency and oxidative stress contribute to the pathogenesis of sarcopenia in patients with CKD," Da Hea Seo, MD, from the division of endocrinology and metabolism in the department of internal medicine at Inha University College of Medicine, Incheon, South Korea, and colleagues wrote.

A total of 3123 patients with T2DM with preserved renal function were followed up for incident CKD. Skeletal muscle mass was estimated from bioelectrical impedance analysis. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2. Sarcopenic obesity was defined as the coexistence of sarcopenia and abdominal obesity.