Specific Antihypertensives Might Prevent Onset Of Diabetes: LANCET
Diabetes affects about 9% of the adult population worldwide, with a rising prevalence in many regions. In a recent study, researchers of the University of Bristol reported that blood pressure lowering is an effective strategy for the prevention of new-onset type 2 diabetes. They also reported that specific blood pressure-lowering medications reduce the onset risk of diabetes. The study findings were published in the journal The Lancet on November 13, 2021.
Blood pressure-lowering is an established strategy for preventing microvascular and macrovascular complications of diabetes. However, its role in the prevention of diabetes itself is unclear. Therefore, Prof Kazem Rahimi, FRCP and his team conducted a study to examine this question using individual participant data from major randomised controlled trials.
They conducted a one-stage individual participant data meta-analysis, in which data were pooled to investigate the effect of blood pressure-lowering on the risk of new-onset type 2 diabetes. They used individual participant data network meta-analysis to investigate the differential effects of five major classes of antihypertensive drugs on the risk of new-onset type 2 diabetes. They included a total of 19 randomised controlled trials in the one-stage individual participant data meta-analysis and 22 trials in the individual participant data network meta-analysis. The trials included were primary and secondary prevention trials that used a specific class or classes of antihypertensive drugs versus placebo or other classes of blood pressure-lowering medications that had at least 1000 persons-years of follow-up in each randomly allocated arm. They used stratified Cox proportional hazards model and logistic regression models to calculate the relative risk (RR) for drug class comparisons.
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