Tobacco Use Associated with latent autoimmune diabetes in genetically susceptible individuals
Sweden: An original article published in Diabetes Care Journal, American Diabetes Association, written by Jessica Edstorp from the Institute of Environmental Medicine, Karolinska Institute, has addressed the role of genetic susceptibility for latent autoimmune diabetes (LADA) and type 2 diabetes in mediating the relationship between tobacco use and the onset of LADA or type 2 diabetes.
They found no role of genetic susceptibility in increasing type 2 diabetes risk in persons with a history of tobacco use. However, LADA risk increase in individuals with genetic susceptibility and tobacco use.
Previous studies have mentioned the association between Smoking and Swedish smokeless tobacco (snus) and latent autoimmune diabetes in adults with LADA and T2D.
Considering this background, researchers investigated the role of genetic susceptibility to T2D, insulin resistance (IR), and insulin secretion (IS) using data from two population-based Scandinavian studies.
The study results could be summarised as follows:
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