Type 2 diabetes drug improves weight loss, blood sugar in certain Type 1 patients with obesity: Study

• Reduced time spent with low blood sugar (lower than 70 mg/dl) to less than 4%.

• Lost at least 5% of their body weight.

None of the 36 patients taking a placebo achieved all three of these milestones.

Those patients taking semaglutide lost an average of 20 pounds without any observed severe complications.

There were two severe hypoglycemia events in each group and no diabetic ketoacidosis was reported.

Semaglutide is part of a class of drugs known as glucagon-like peptide-1, or GLP-1, receptor agonists. Although introduced as a Type 2 diabetes medication, it has recently gained prominence as a weight-loss drug.

"We hope that our trial will encourage the industry to conduct a regulatory approval trial so that this drug could be available as an adjunct to insulin therapy to optimize Type 1 diabetes management," Shah said.

This research was funded by Breakthrough T1D.

Giorgos Bakoyannis, PhD, adjunct associate professor of biostatistics and health data science, was a co-author on the study. Shah and Bakoyannis were joined by researchers from the University of Colorado Anschutz Medical Campus, Henry Ford Health, Iowa Diabetes Research, University of Washington and Oregon Health & Science University.