Vitamin D deficiency not associated with insulin resistance or beta-cell function
There is no association between vitamin D deficiency and insulin resistance or beta-cell function according to a recent study published in the Journal of the Association of Physicians of India
Vitamin D plays an important role in bone and modulates mineral metabolism and immune function with a probable link to several chronic and infectious conditions. In vivo studies have revealed that vitamin D deficiency reduces the insulin secretion capacity of the islet beta cells in the pancreas. Several studies have shown a correlation between vitamin D levels and insulin resistance, nonetheless, extensive studies showing the relationship between the two are lacking especially among the southern Indian population. So the present study was aimed at evaluating the relationship between vitamin D and insulin resistance by using the homeostatic model assessment-insulin resistance (HOMA-IR).
In a cross-sectional study, 184 people among which 92 were diabetic and 92 were nondiabetic were recruited at RL Jalappa Hospital, Kolar in the Department of Medicine between May 2018 and April 2019. Fasting serum insulin (I0), fasting plasma glucose (G0), haemoglobin A1c (HbA1C), renal function test, liver function test (LFT), lipid profile, and vitamin D levels were estimated. IBM SPSS version 22 was used for statistical analysis.
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