Vitamin D supplements in Prediabetes patients reduce type 2 diabetes risk, says study

The researchers performed a database search of PubMed/MEDLINE, EMBASE, and the Cochrane Library from inception through September 15, 2019. RCTs that reported the effect of vitamin D supplementation for at least 1 year on T2D prevention, were included.

Two independent reviewers extracted the data. The risk ratios (RRs) and 95% confidence intervals (CIs) were reported. The primary outcome of the meta-analysis was the incidence of T2D.

A total of nine RCTs with 43 559 participants, were included. The mean age (standard deviation) was 63.5 (6.7) years. 

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Key findings of the study include:

"In patients with prediabetes, vitamin D supplementation at moderate to high doses (≥1000 IU/day), significantly reduced the incidence risk of T2DM, compared with placebo," concluded the authors.

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The study, "Effect of Vitamin D Supplementation on the Incidence of Diabetes Mellitus," is published in the Journal of Clinical Endocrinology & Metabolism.

DOI: https://doi.org/10.1210/clinem/dgaa335