Women more prone to episodes of hypo and hyperglycemia during and after pregnancy after RYGB surgery
Denmark: Pregnant women with a history of Roux-en-Y gastric bypass (RYGB) surgery are more exposed to hyper- and hypoglycemia than their peers without an RYGB history, claims a study published in Diabetes Care.
Roux-en-Y gastric bypass surgery is the most frequently performed bariatric procedure worldwide and significantly affects weight loss and diabetes remission.
RYGB and pregnancy noticeably alter glucose metabolism, but there is not much evidence of glucose metabolism in pregnancy after RYGB. Thus, Louise L. Stentebjerg from Odense University Hospital in Odense, Denmark, and colleagues set out to investigate interstitial glucose (IG) profiles during pregnancy, the association between the growth of fetus and hypoglycemia in pregnant patients previously underwent RYGB surgery versus control participants, and risk factors linked with hypoglycemia.
For this purpose, the researchers prospectively studied twenty-three pregnant women with RYGB and 23 BMI- and parity-matched pregnant women taken as a control group. Continuous glucose monitoring was done in their first, second, and third trimesters and four weeks postpartum. TIR (time in range) was defined as time with an interstitial glucose level of 3.5–7.8 mmol/L.
The study led to the following findings:
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