Folic Acid Supplements may Benefit Patients with IBD
Homocysteine and Bone Mineral Density (BMD) in IBD
Inflammatory bowel disease patients present an increased risk of low BMD, leading to osteoporosis. Among others, risk factors of osteoporosis in IBD include malnutrition, low body mass, malabsorption, or use of corticosteroids. Although the studies describing the association between IBD and homocysteine focused on non-IBD individuals, the researchers suggest that hyperhomocysteinemia may constitute a potential additional factor of low BMD among IBD patients.
Microbiota and Folate Metabolism in IBD Patients
Many factors can affect the gut microbiota in patients with inflammatory bowel disease, such as age, inhabitable environment, culture, habits, medical history, and the applied treatment.
The researchers reported that the probiotic supplementation containing Bifidobacterium and Lactobacillus Plantarum strains may increase folic acid production in patients with IBD and have a protective function for colonocytes in the course of this disease. Additionally, they noted that microbial folate synthesis may also be affected by certain drugs such as metformin and sulfonamides.
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