Prophylactic antibiotics fail to reduce infection rate following clean conventional myringoplasty
In clean conventional myringoplasty, prophylactic antibiotics do not improve the chance of having a healed tympanic membrane at follow-up. It also does not decrease the risk of a postoperative infection within six weeks, says Dr Westman in his recent study published in Clinical Otolaryngology.
In this study, “Prophylactic antibiotics have no benefit for outcome in clean myringoplasty-A register-based cohort study from SwedEar”, co-author Maria Höglund said that the main objective of our research was To investigate whether prophylactic antibiotics (PA) in conjunction with myringoplasty of clean and uninfected ears reduces postoperative infections within six weeks after surgery, and whether it affects or not the healing rate of the tympanic membrane (TM) at follow-up, 6-24 months after surgery. We extracted data from The Swedish Quality Register for Ear Surgery (SwedEar), the years 2013-2019 noted.
The patients included had registered clean conventional myringoplasty with follow-up visits.
The primary outcome measures included in the study were the effect of PA use on TM healing rate at follow-up and postoperative infection within six weeks of surgery.
The results of the study are:
- There were 1665 participants in the study group.
- At follow-up, 86.2% had a healed tympanic membrane.
- They reported no significant difference between the groups with/ without PA administration constituting 87.2% and 86.1%, respectively.
- Within six weeks, 8.0% had a postoperative infection.
- In the group receiving prophylactic antibiotics, 10.2 %had Postoperative infection compared with 7.7% of the group that did not receive PA.
- Postoperative infection within six weeks reduced the frequency of healed TMs.
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