A vibrating ingestible device to help treat obesity, find researchers
The obesity epidemic, affecting nearly 42% of US adults (1, 2), increasingly strains healthcare resources by increasing the incidence of comorbidities such as diabetes, hypertension, cancer, and heart disease
Effective therapies for obesity require invasive surgical and endoscopic interventions or high patient adherence, making it challenging for patients with obesity to effectively manage their disease.
Gastric mechanoreceptors sense distension of the stomach and perform volume-dependent vagal signaling to initiate the gastric phase and influence satiety. A new study in Science Advances reports an ingestible electronic vibrator created a euphoric state of fullness and caused less intake of food helping in treating obesity.
Vagal nerve signaling plays a critical role in satiation through a negative feedback loop in which anorexigenic neurometabolic secretions are released in response to food intake Distension of the stomach by food contents is transduced by intraganglionic laminar endings (IGLEs), the most prevalent type of vagal afferents innervating the gastric musculature, which sense contraction and distension
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