Abnormal Thyroid Hormone Levels Independently Associated with MASH Risk: Study
Researchers have discovered in a new study that abnormal serum thyroid hormone levels are independently correlated with a higher risk of metabolic steatohepatitis (MASH) in patients with normal thyroid function. The findings suggest a possible role of thyroid hormones as biomarkers for the identification of patients at greater risk of MASH. Metabolic steatohepatitis is a severe liver disease frequently associated with the wider spectrum of non-alcoholic fatty liver disease (NAFLD). The study was conducted by Chun-Yan Yang and fellow researchers published in the journal Digestive and Liver Disease.
MASH is a progressive type of fatty liver disease that may result in liver fibrosis, cirrhosis, and even liver cancer if not treated. Although various metabolic abnormalities such as obesity and insulin resistance are well-documented to contribute, the possible role of thyroid hormone disturbances in those without clinical thyroid disease has gained more interest. Thyroid hormones have a central role in lipid metabolism and liver function regulation. Knowing that their connection to MASH would provide new doors for risk evaluation and early intervention in NAFLD at-risk individuals.
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