Amoxicillin-clavulanate reduces drug-induced side effects in diverticulitis patients: Study
USA: Diverticulitis treatment with amoxicillin-clavulanate reduces the risk for fluoroquinolone-related harms without negatively affecting diverticulitis-specific outcomes, a recent study has found. The study findings appear in the Annals of Internal Medicine.
Outpatient diverticulitis is generally treated with amoxicillin-clavulanate or a combination of metronidazole and a fluoroquinolone (metronidazole-with-fluoroquinolone). The FDA suggested reserving Fluoroquinolones for conditions with no other alternatives.
This sparked Dr. Charles E Gaber and his team to compare the benefits and shortcomings of metronidazole-fluoroquinolone and Amoxicillin-Clavulanate combination for outpatient diverticulitis. They found that amoxicillin-clavulanate reduces the risk for fluoroquinolone-related harms without adversely affecting outcomes.
This study was based on claims data on U.S. citizens aged 18 to 64 with private employer-sponsored insurance from 2000 to 2018 and those aged 65 and over with Medicare from 2006 to 2015. Immunocompetent adults were grouped randomly into the Metronidazole-with-fluoroquinolone group and the amoxicillin-clavulanate group.
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