Aspirin tied to reduced risk of mortality, sepsis, and shock among IBD patients

The study could be summarised as follows:

• The study included 1,524,820 IBD hospitalizations.
• 137,430 patients were long-term aspirin users.
• In the aspirin group, 34% of patients were aged > 65 years, 56% were female, 78% were White, and 36% had Medicare insurance.
• Aspirin users had a lower incidence of in-hospital mortality (1.6% vs 1.4%), sepsis (2.5% vs 2.9%), shock (2.9% vs 3.4%), ICU admission (2.6% vs 2.9%), and surgery need (2.1% vs 4.2%).
• After adjusting for confounders, aspirin was associated with a reduction in mortality having adjusted odds ratio of 0.49.

They said, Our study used an extensive NIS database to assess the outcomes of patients hospitalized with IBD taking aspirin. Previous literature has shown that White patients are more likely to be taking long-term aspirin even when controlling for cardiovascular risk factors. These findings suggest that the study sample is representative of the population taking aspirin. The study also found lower odds of surgical intervention in patients with long-term aspirin use, which may be due to the effect of aspirin on the disease activity among IBD patients. The incidence of surgical intervention in the study was 4%.

Reference:

Iqbal H et al. The impact of aspirin use on outcomes in patients with inflammatory bowel disease: Insights from a national database. Int J Colorectal Dis. 2023 Dec 20;39(1):6