Coffee intake associated with low liver stiffness but not steatosis

The key findings of this study were:

1. The study group mentioned had an average age of 48 ± 0.6 years, was overweight or obese in 73% of cases, had diabetes in 10.6% of cases, engaged in vigorous physical activity in 47.5% of cases, and consumed two or more alcoholic beverages in 23% of cases.

2. Coffee and controls with CAP had no relation after multivariate correction.

3. With no other beverages consumed, those who drank more than three cups of coffee had a 0.9 lower kPa.

4. A LSM of 9.5 kpa or higher required more than 3 cups of coffee to be protective.

5. Only drinking more than three cups of coffee per day remained a significant independent predictor of LSM after accounting for other liquids in the same model.

6. At any dosage, caffeine had no discernible relationship with LSM.

7. Finally, after correcting for the use of sugar-sweetened beverages and the Healthy Eating Index-2015, coffee consumption was still linked to a lower LSM.

8. Because of this, coffee's beneficial effects cannot be attributed to caffeine and remain in individuals regardless of the quality of their diet.

Reference: 

Niezen, S., Mehta, M., Jiang, Z. G., & Tapper, E. B. (2022). Coffee Consumption Is Associated With Lower Liver Stiffness: A Nationally Representative Study. In Clinical Gastroenterology and Hepatology (Vol. 20, Issue 9, pp. 2032-2040.e6). Elsevier BV. https://doi.org/10.1016/j.cgh.2021.09.042