Compared with diclofenac, buprenorphine more effective for Pain Relief in Acute Pancreatitis: Study
Compared with diclofenac, buprenorphine is more effective for Pain Relief in Acute Pancreatitis suggests a new study published in the Clinical Gastroenterology and Hepatology.
Although both nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids are used for analgesia in acute pancreatitis (AP), the analgesic of choice is not known. They compared buprenorphine, an opioid, and diclofenac, an NSAID, for analgesia in acute pancreatitis In a double-blind randomized controlled trial, acute pancreatitis patients were randomized to receive intravenous diclofenac or intravenous buprenorphine. Fentanyl was used as rescue analgesia, delivered through a patient-controlled analgesia pump. The primary outcome was the difference in the dose of rescue fentanyl required. Secondary outcomes were the number of effective and ineffective demands of rescue fentanyl, pain-free interval, reduction in visual analogue scale (VAS) score, adverse events, and organ failure development. Results: Twenty-four patients were randomized to diclofenac and 24 to buprenorphine. The 2 groups were matched at baseline. The total amount of rescue fentanyl required was significantly lower in the buprenorphine group:130 μg, interquartile range (IQR), 80–255 vs 520 μg, IQR, 380–1065 (P < .001).
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