Corticosteroids use in IBD Patients may increase COVID-19 complication
Individuals with inflammatory bowel disease (IBD) under corticosteroids are at elevated risk for severe COVID-19 complications. The findings were published in Inflammatory Bowel Diseases.
The retrospective cohort study, spanning from August 2019 to August 2021, enrolled a substantial 102,986 patients with IBD (48,728 with Crohn's disease and 47,592 with ulcerative colitis), with an average age of 53, of which 55% were female. The research delved into the utilization of various IBD medications in the 90 days preceding cohort entry, tracking patient outcomes through COVID-19 hospitalization, mechanical ventilation or inpatient death.
Preliminary findings indicate that 0.4% of the IBD patients (412 individuals) required hospitalization due to COVID-19. Notably, patients using corticosteroids exhibited a higher incidence of hospitalization (0.6% compared to 0.3% in non-users).
This trend translated to an increased likelihood of needing mechanical ventilation for corticosteroid users (1.9% compared to 0.05% in non-users), with a similar pattern observed in inpatient deaths due to COVID-19. In contrast, patients receiving anti-tumor necrosis factor α therapy showcased a lower rate of hospitalization (0.2% compared to 0.5% in non-users), suggesting a potential protective effect.
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