Exploring Link Between Gut Microbiota and Pancreatitis: A Systematic Review
China: A comprehensive and systematic study published in Apollo Medicine has provided strong evidence supporting the complex relationship between pancreatitis and the microbiota.
The human gastrointestinal tract is home to a vast and diverse microbial community, comprising over 10 bacteria and containing more than 5 million genes.
The study led by Xu Zhang, Department of Laboratory Medicine, School of Medicine, Jiangsu University et. al. aims to systematically review human research to explore the relationship between gut microbiota and pancreatic disorders.
For this study, relevant research from 2011 to 2022 was systematically compiled through an extensive search of the MEDLINE and EMBASE databases. The initial search results, encompassing all identified studies, underwent a detailed examination, including a thorough review of their reference lists to ensure a comprehensive search. The initial search yielded 114 items, but 58 duplicate articles were subsequently removed. A meticulous screening process, which involved assessing titles, abstracts, and keywords, led to 36 studies advancing to the next phase of evaluation. However, further scrutiny resulted in the exclusion of 11 studies classified as reviews or case reports, 5 non-English publications, and 20 that did not focus on the microbiome. Ultimately, a refined set of 20 papers was selected for in-depth eligibility evaluation.
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