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FIT after negative colonoscopy may reduce risk of colorectal cancer: Study

Written By :  Dr. Nandita Mohan
Medically Reviewed By :  Dr. Kamal Kant Kohli
Published On 2021-07-07 03:30 GMT   |   Update On 2021-07-07 05:18 GMT
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Subsequent faecal immunochemical test (FIT) should be scheduled after negative colonoscopy to detect missed neoplasms, thereby reducing the risk of incidence of colorectal cancer (CRC), finds a recent study as published in The Gut Journal.

Subjects with a positive faecal immunochemical test (FIT) have a much higher likelihood of advanced neoplasms than the general population. Whether FIT-positive subjects with negative colonoscopy should receive subsequent FIT screening remain unclear.

Hence, Szu-Min Peng and associates from the Division of Biostatistics, College of Public Health, National Taiwan University, Taipei, Taiwan recently carried out a cohort study, which comprised of 9179 subjects who had negative diagnostic colonoscopy after positive FIT, of whom 6195 received subsequent FIT during the study period.

Subjects with a negative colonoscopy after positive FIT in the first screening in the Taiwanese Colorectal Cancer (CRC) Screening Program were followed up. CRC incidence was compared between those who did and did not receive subsequent FIT screening.

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Cox regression analysis was conducted, adjusting for major confounders to investigate whether subsequent FIT was associated with lower risk of incident CRC.

The study revealed that the CRC incidence (per 1000 person years) was 1.34 in those who received subsequent FIT and 2.69 in those who did not, with corresponding adjusted HR (aHR) of 0.47 (95% CI 0.31 to 0.71). Lower adenoma detection rate of diagnostic colonoscopy was associated with higher risk of incident CRC but became non-significant in multivariable analysis after adjustment for subsequent FIT.

Higher baseline faecal haemoglobin concentration (FHbC, μg haemoglobin/g faeces) was associated with increased risk of incident CRC, 0.95, 2.26 and 2.44 for FHbC=40–59, 60–99, 100–149 and ≥150, respectively.

As a results, the authors concluded that "subsequent FIT should be scheduled after negative colonoscopy to detect missed neoplasms and reduce the risk of incident CRC in a national FIT screening programme."

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Article Source : The Gut Journal

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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