H. pylori eradication associated with improvement and cure of FD symptoms: Study
H. pylori eradication is associated with the improvement and cure of functional dyspepsia (FD) symptoms, according to a recent study published in the Gut.
Functional dyspepsia (FD) is a chronic disorder that is difficult to treat. Helicobacter pylori may contribute to its pathophysiology. A Cochrane review from 2006 suggested that eradication therapy was beneficial, but there have been numerous randomised controlled trials (RCTs) published since. We evaluated the impact of eradication therapy on both cure and improvement of functional dyspepsia, as well as whether any benefit was likely to arise from the eradication of H. pylori.
They searched the medical literature through October 2021 to identify RCTs examining the efficacy of eradication therapy in H. pylori-positive adults with functional dyspepsia. The control arm received antisecretory therapy or prokinetics, with or without placebo antibiotics, or placebo alone. Follow-up was for ≥3 months. They pooled dichotomous data to obtain a relative risk (RR) of symptoms not being cured or symptoms not improving with a 95% CI. Researchers estimated the number needed to treat (NNT).
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