H. pylori treatment reduces risk of gastric cancer in high-risk patients: NEJM
South Korea: Helicobacter pylori eradication treatment may reduce the risk of gastric cancer in patients with the infection having a family history of gastric cancer in first-degree relatives, a recent study in the New England Journal of Medicine has suggested.
H. pylori, a gram-negative and spiral-shaped bacterium that dwells on the gastric epithelium, is known to be associated with gastrointestinal diseases such as gastric ulcer, stomach cancer, and gastritis. Therefore, its eradication is of great importance. A family history of gastric cancer and H. pylori infection at the main risk factors for gastric cancer. It is not known whether treatment for H. pylori can reduce gastric cancer in people with a family history of gastric cancer in first-degree relatives.
Il Ju Choi, Center for Gastric Cancer, National Cancer Center, Gyeonggi, South Korea, and colleagues screened 3100 first-degree relatives of patients with gastric cancer in this single-center, double-blind, placebo-controlled trial. 1838 participants with H. pylori infection were randomly assigned to receive either eradication therapy (lansoprazole [30 mg], amoxicillin [1000 mg], and clarithromycin [500 mg], each taken twice daily for 7 days) or placebo.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.