Insulin Resistance frequent in Non-Diabetics with NAFLD, reports research

At Karachi's Liaquat National Hospital two groups of 362 non-diabetic individuals with NAFLD were created: one with IR and one without. In order to assess hepatic steatosis, a physical examination, a clinical history, laboratory tests (fasting lipid profile, insulin, fasting glucose, and liver function tests), and abdominal ultrasonography with fibroscan were conducted. Hepatic steatosis was defined as having a Controlled Attenuation Parameter (CAP) score of > 238 dB/m, and metabolic syndrome was identified using certain clinical and laboratory criteria. Data analysis was done with SPSS version 27.

Of the 362 patients that were enrolled, 51.7% were men. Of the individuals, 311 (84.9%) exhibited insulin resistance. For HDL, FPG, LDL, fasting plasma insulin, and GGT, there were notable differences in insulin resistance. Insulin resistance is less common in male patients than in female individuals. individuals with metabolic syndrome are more likely than non-metabolic individuals to have insulin resistance. Overall, this study found that IR is highly prevalent among non-diabetic individuals with NAFLD in Pakistan, and a significant percentage of these patients are also obese.

Reference:

Kamani, L., Siddiqui, M., & Rahat, A. (2025). Frequency of insulin resistance among non-diabetic patients with non-alcoholic fatty liver disease using HOMA-IR: an experience of a tertiary care hospital in Karachi, Pakistan. BMC Gastroenterology, 25(1), 259. https://doi.org/10.1186/s12876-025-03790-6