Intragastric balloons With Lifestyle Modification lead to significant Weight Loss: Lancet
Several strategies are available to address the obesity epidemic and range from noninvasive lifestyle interventions to medications and bariatric surgical procedures.
In a recent study, researchers have found that adjustable intragastric balloons combined with lifestyle modification help to achieve weight loss and maintain it for 6 months following removal. The study findings were published in the journal The Lancet on November 15, 2021.
Intragastric balloons are anatomy-preserving, minimally invasive obesity therapies. Enhanced tolerance and durability could help broaden clinical adoption. Enhancing its tolerance and durability could help broaden clinical adoption. Therefore, Prof Barham K Abu Dayyeh, MD and his team investigated the safety and efficacy of an adjustable intragastric balloon (aIGB) in adults with obesity.
It was a prospective, multicentre, open-label, randomized clinical trial done at seven US sites. The researchers included a total of 288 patients with obesity and randomized them to aIGB (n=187 [65%]) with a lifestyle intervention group and with lifestyle intervention alone (n=101 [35%]) group (control group). They determined balloon volume could be increased to facilitate weight loss or decreased for tolerability. The primary endpoints of the study were mean percentage total body weight loss and responder rate (≥5% total body weight loss) at 32 weeks. The researchers used a multiple imputed intention-to-treat population analysis.
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