Lactate-to-albumin ratio may independently predict adverse outcomes in sepsis-associated liver injury patients

The mortality rate of sepsis-associated liver injury (SALI) is relatively high, but there is currently no authoritative prognostic criterion for the outcome of sepsis-associated liver injury. Meanwhile, the lactate-to-albumin ratio has been confirmed to be associated with mortality rates in conditions such as sepsis, heart failure, and respiratory failure. However, research reporting is scarce on the association between lactate-to-albumin ratio and sepsis-associated liver injury. This study aimed to elucidate the association between the lactate-to-albumin ratio and the 28-day mortality rate of sepsis-associated liver injury. In this retrospective cohort study, data were obtained from the Medical Information Mart for Intensive Care IV (v2.2). Adult patients with sepsis-associated liver injury were admitted to the intensive care unit in this study. The lactate-to-albumin ratio level at admission was included, and the primary aim was to assess the relationship between the lactate-to-albumin ratio and 28-day all-cause mortality. Results: A total of 341 patients with sepsis-associated liver injury were screened. They were divided into a survival group (241) and a non-survival group (100), and the 28-day mortality rate was 29.3%. Multivariable Cox regression analysis revealed that for every 1-unit increase in the lactate-to-albumin ratio, the 28-day mortality risk for sepsis-associated liver injury patients increased by 21%, with an HR of 1.21 This study indicates that in patients with SALI, a higher LAR is associated with an increased risk of all-cause mortality within 28 days of admission. This suggests that LAR may serve as an independent risk factor for adverse outcomes in SALI patients.

Reference:

Yi X, Jin D, Huang S, Xie Z, Zheng M, Zhou F, Jin Y. Association between lactate-to-albumin ratio and 28-days all-cause mortality in patients with sepsis-associated liver injury: a retrospective cohort study. BMC Infect Dis. 2024 Jan 9;24(1):65. doi: 10.1186/s12879-024-08978-x. PMID: 38195421; PMCID: PMC10775525.

Keywords:

Lactate-to-albumin ratio, independent risk factor liver, adverse outcomes liver, sepsis-associated liver injury, Yi X, Jin D, Huang S, Xie Z, Zheng M, Zhou F, Jin Y, Lactate-to-albumin ratio, Liver injury, All-cause mortality, 28-days, Sepsis, MIMIC IV, BMC Infectious Diseases