Long-term use of PPIs not linked to all-cause mortality or gastroenterology complications: AGA
USA: In a new study conducted by Chun-Han Lo and the team it was shown that after controlling for protopathic bias, proton pump inhibitor (PPI) usage was not linked with an increased risk of all-cause mortality or gastroenterology complications. The findings of this study were published in the Gastroenterology journal.
Proton-pump inhibitors (PPIs) are a family of medications well recognized for their usage in acid-related illnesses. Omeprazole, medicine in this family, is one of the top ten most prescribed medications in the United States. PPIs are heterocyclic organic compound benzimidazole derivatives. They are frequently used as first-line agents by gastroenterologists.
Researchers used data from the Nurses' Health Study (2004-2018) and the Health Professionals Follow-up Study to perform a prospective cohort study (2004-2018). The hazard ratios (HRs) and 95 percent confidence intervals (CIs) for death based on PPI usage were estimated using Cox proportional hazards models. To reduce reverse causality, they used a modified lag-time technique (i.e., protopathic bias).
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