Low iron levels closely associated with higher risk of coeliac disease: BMJ
A recent study explored the complex interplay between genetics and health and uncovered a potential environmental trigger for the rising prevalence of coeliac disease. The key findings of the study were published in the recent edition of BMJ Open Gastroenterology.
This study utilized Mendelian randomization which suggests a significant association between iron deficiency and the development of this autoimmune condition. The two-sample Mendelian randomization study were conducted to explore the relationship between single nucleotide polymorphisms (SNPs) associated with the iron status and the presence of coeliac disease.
The findings revealed four SNPs that were strongly linked to systemic iron status. These genetic variants were not associated with known risk factors for coeliac disease that indicated a distinct pathway in disease development. This research used data from the UK Biobank that encompassed a vast group of over 336,000 individuals, including 1,855 diagnosed with coeliac disease and meticulously examined the genetic landscape.
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