NG Feeding Increase Risk of Diarrhea and Infection Within 48 Hours of Admission: BMC

Following PRISMA guidelines, this systematic review examined studies from PubMed, EMbase, Cochrane Central Register of Controlled Trials, and Web of Science. Search terms such as "Pancreatitis," "NG feeding," "Nasojejunal feeding," and "mortality" were employed to select randomized controlled trials (RCTs) focusing on NG or NJ feeding in AP patients within 72 hours of admission. Exclusions encompassed non-English articles, case reports, and non-RCTs. Rigorous data extraction and quality assessment were conducted using Cochrane's risk of bias tool, and statistical analyses included risk ratios (RR) and standardized mean differences (SMD) to assess heterogeneity via I² statistics. Subgroup analyses explored variables such as patient age and the impact of early intervention within 48 hours post-admission.

The meta-analysis findings revealed comparable mortality rates between NG and NJ feeding groups. Notable differences emerged, however, with the NG group expressed higher rates of diarrhea, pain, infection probabilities, and more frequent instances of multiple organ failure. Subgroup analysis focusing on early intervention underscored an elevated risk of diarrhea in the NG group. Conversely, no significant disparities were found regarding the need for surgical intervention, parenteral nutrition requirements, or the success rates of feeding procedures.

This study suggests that both NG and NJ feeding methods are similarly effective in the initial management of acute pancreatitis, without significant differences in mortality or primary clinical outcomes. The choice of feeding route should be tailored to individual patient characteristics and clinical contexts.

Reference:

Wang, M., Shi, H., Chen, Q., Su, B., Dong, X., Shi, H., & Xu, S. (2024). Comparative safety assessment of nasogastric versus nasojejunal feeding initiated within 48 hours post-admission versus unrestricted timing in moderate or severe acute pancreatitis: a systematic review and meta-analysis. In BMC Gastroenterology (Vol. 24, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12876-024-03290-z