Non-Antibiotic Outpatient Treatment effective for Mild Acute Diverticulitis: Study

A total of 480 patients were then randomized to either a control group (ATB-Group; n = 238): classical treatment (875/125 mg/8 h amoxicillin/clavulanic acid apart from anti-inflammatory and symptomatic treatment) or experimental group (Non-ATB-Group; n= 242): experimental treatment (anti-inflammatory and symptomatic treatment). Clinical controls were performed at 2, 7, 30, and 90 days.

The primary endpoint was hospital admission, while the secondary endpoints included a number of emergency department revisits, pain control and emergency surgery in the different arms.

The findings of the study are as follows:

· The hospitalization rats were more in the ATB group (5.8%) as compared to the Non-ATB group (3.3%)

· Hospital revisits in both the groups were almost the same; ATB group (6.7%) and Non-ATB group (7%)

· While for poor pain control at 2 days follow up was worse in the ATB-Group (5.7%) as compared to the Non-ATB-Group (2.3%)

The researchers concluded that non-antibiotic outpatient treatment for mild Acute Diverticulitis is also safe and equally effective when compared with the current standard treatment.

Reference:

Efficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial by Laura M et. al in the Annals of Surgery.

DOI: 10.1097/SLA.0000000000005031