Pentraxin 3 accurately predicts advanced fibrosis and CIMT in patients with MAFLD: Study
Background and objectives
Metabolic-associated fatty liver disease (MAFLD) may increase the risk of cardiovascular events. In this study, we assessed the predictive value of pentraxin 3 (PTX3) for severe fibrosis and carotid intima-media thickness (CIMT) in patients with MAFLD.
Methods
188 patients (114 with MAFLD, 74 with dual etiology MAFLD and chronic hepatitis C) were included. All participants underwent clinical history and examination, metabolic parameter assessment, serum level evaluation of PTX3, Fibrosis-4 index and nafld fibrosis score scores, abdominal ultrasound, and CIMT assessment.
Results
The serum PTX3 was significantly elevated in patients with advanced fibrosis compared to those with mild/moderate fibrosis (1.8 vs 1.4, p = 0.006). The PTX3 level was independently associated with advanced fibrosis (odds ratio = 1.26, 95% confidence interval 1.008–1.040). In MAFLD patients, the PTX3 levels in patients with low fibrosis compared to those with advanced fibrosis were 1.4 (1–2.1) and 1.9 (1.3–3.8), respectively (p = 0.027). A significantly greater CIMT was noted in patients with elevated PTX3 levels (3.85 (3.42–4) vs 4.05 (3.7–4.67), p = 0.0001) compared to those with low PTX3 levels.
Conclusions
In this study, we demonstrated that PTX3 accurately predicts the presence of advanced fibrosis and CIMT in a population with MAFLD. Thus, it could be useful for risk stratification and management. Further independent studies will be required to confirm these findings in larger cohorts and in the general population, which has diverse representations of individuals of other races and ethnicities.
References: Alshymaa A. Hassnine1,* , Yasser Fouad1, Zienab M. Saad1, Alaa M. Mostafa1, Hend M. Moness2, Nehal I. Abbas2, Nasr M. Osman3 and Wafaa Abdelghany1
Author information Gene Expression 2024doi: 10.14218/GE.2023.00047
Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement/treatment or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2024 Minerva Medical Treatment Pvt Ltd